IRF1, IRF8 and partners: epigenetic regulators of normal and pathological inflammation

IRF1、IRF8 及其伙伴：正常和病理性炎症的表观遗传调节因子

• 批准号: 410255
• 负责人: Langlais David
• 金额: $ 55.17万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-09-01 至 2024-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=410255&lang=en
• 关键词: Cerebral Malaria; Complex Inflammatory Diseases; Epigenomics; Gene Expression; Inflammation; Innate Immunity; Interferon Regulatory Factor (Irf); Mouse Models; T Cell Function; Transcription Factors

Genetic variations and environmental factors influence host immune responses and can lead to susceptibility to pathogens and to inflammatory diseases. Two regulators of gene expression in immune cells, the transcription factors IRF1 and IRF8, have been im

遗传变异和环境因素影响宿主免疫反应，并可导致对病原体和炎症性疾病的易感性。免疫细胞中基因表达的两个调节因子，转录因子IRF1和IRF8，已经被发现