Evaluation of the mechanistic interplay between psychobiotic microbes and human gut microbiota challenged with psychotropic chemicals

评估精神微生物与受到精神药物挑战的人类肠道微生物群之间的机制相互作用

• 批准号: 543626-2019
• 负责人: Hammami, Riadh
• 金额: $ 1.82万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=680689
• 关键词: Evaluation; mechanistic; interplay; between; psychobiotic

Probiotic strains Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 improved psychological well-being and cognitive reactivity, decreased cortisol levels, and modulated brain neural activity among healthy volunteers1. However, there is a limited understanding of the probiotic mechanism underlying the dynamic interplay between these microbes and healthy human colonic microbiota, a prerequisite for the design of robust new nutraceuticals. The project aims to elucidate the mechanism of action of these probiotics on the healthy human gut microbiota. The project is focusing on probiotics' (a) molecular competition with intestinal bacteria in vitro; (b) susceptibility to psychotropic chemicals as affected by gastrointestinal stresses; and (c) mechanistic interplay with healthy human colonic microbiota.

益生菌菌株瑞士乳杆菌R 0052和长双歧杆菌R 0175改善了健康志愿者的心理健康和认知反应，降低了皮质醇水平，并调节了大脑神经活动。然而，对这些微生物与健康人类结肠微生物群之间动态相互作用的益生菌机制的理解有限，这是设计强大的新营养品的先决条件。该项目旨在阐明这些益生菌对健康人体肠道微生物群的作用机制。该项目的重点是益生菌（a）与体外肠道细菌的分子竞争;（B）受胃肠道压力影响对精神药物的敏感性;（c）与健康人类结肠微生物群的机械相互作用。