Evaluation of the mechanistic interplay between psychobiotic microbes and human gut microbiota challenged with psychotropic chemicals

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Probiotic strains Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 improved psychological well-being and cognitive reactivity, decreased cortisol levels, and modulated brain neural activity among healthy volunteers1. However, there is a limited understanding of the probiotic mechanism underlying the dynamic interplay between these microbes and healthy human colonic microbiota, a prerequisite for the design of robust new nutraceuticals. The project aims to elucidate the mechanism of action of these probiotics on the healthy human gut microbiota. The project is focusing on probiotics' (a) molecular competition with intestinal bacteria in vitro; (b) susceptibility to psychotropic chemicals as affected by gastrointestinal stresses; and (c) mechanistic interplay with healthy human colonic microbiota.