Engineering the design of regulatory T cell therapy in transplantation

移植中调节性 T 细胞疗法的设计

• 批准号: 412594
• 负责人: Rosado Sánchez Isaac
• 金额: $ 9.83万
• 依托单位: BC Children's Hospital Research Institute
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-10-01 至 2022-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=412594&lang=en
• 关键词: Car Treg; Cell Therapy; Chimeric Antigen Receptors (Car); Crispr/Cas9; Flow Cytometry, Histology And Molecular Biology; In Vivo Models Of Transplantation; Modulation Of Treg Function And Stability; Regulatory T Cell (Treg); Solid Organ Transplant (Sot); T

Solid organ transplantation (SOT) is a curative option for end stage organ failure; however, the success of this procedure depends on life-long use of immunosuppressive drugs which put patients at risk for infections and cancer. Regulatory T cells (Treg)

实体器官移植（SOT）是终末期器官衰竭的治疗选择；然而，这项手术的成功取决于终身使用免疫抑制药物，这使患者面临感染和癌症的风险。