Translating milk pharmacokinetic data into infant plasma level prediction: an application of population pharmacokinetics and infant physiologically-based population pharmacokinetic models to predict drug exposure to breastfeeding infants

将乳汁药代动力学数据转化为婴儿血浆水平预测：群体药代动力学和基于婴儿生理学的群体药代动力学模型的应用，用于预测母乳喂养婴儿的药物暴露

• 批准号: 418070
• 负责人: Yeung Cindy
• 金额: $ 7.65万
• 依托单位: University of Waterloo (Ontario)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-10-01 至 2022-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=418070&lang=en
• 关键词: Drug Safety; Pediatrics; Pharmacokinetics; Women'S Health

Breastfeeding protects the mother and infant against a wide range of diseases and promotes infant development. A staggering 13.8% of all deaths of children <2 years old (823,000 deaths/year) could be prevented if all infants breastfed. Although the choice

母乳喂养保护母亲和婴儿免受各种疾病的侵袭，并促进婴儿发育。如果所有婴儿都用母乳喂养，两岁儿童死亡总数的13.8%(823,000例/年)是可以避免的。尽管这个选择