Polygenic variant patterns explain new pathway-based molecular models of inflammatory bowel disease pathogenesis

多基因变异模式解释了炎症性肠病发病机制的新的基于途径的分子模型

• 批准号: 417561
• 负责人: Mulder Daniel J
• 金额: $ 4.01万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=417561&lang=en
• 关键词: Epistasis; Genomics; Inflammatory Bowel Disease; Molecular Pathway Analysis; Next Generation Sequencing; Pedigree Analysis; Personalized Medicine; Phenotype-Genotype Interactions; Polygenic Inheritance; Whole Exome Sequencing

Inflammatory bowel disease (IBD) has a major impact on the lives of many Canadians. Current estimates are that approximately 1 in 150 Canadians have IBD and this number is steadily increasing. It is estimated that within the next 10 years, IBD will affect

炎症性肠病(IBD)对许多加拿大人的生活有重大影响。目前的估计是，大约每150名加拿大人中就有一人患有IBD，而且这个数字还在稳步上升。据估计，未来10年内，IBD将影响