Iron uptake, utilization and storage in mice

小鼠铁的吸收、利用和储存

• 批准号: RGPIN-2018-06442
• 负责人: Santos, Manuela
• 金额: $ 2.11万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=683147
• 关键词: Iron; uptake; utilization; storage; mice

Iron uptake, utilization and storage in mice******Total iron deficiency is incompatible with life, whereas iron excess is dangerously toxic. Thus, body iron levels in mammals are tightly maintained in balance. Iron metabolism is regulated such that sufficient iron is provided for body needs (to virtually every cell and, in particular, red blood cells), but at the same time avoiding its toxicity through safe storage in specialized molecules, because free iron can participate in the formation of free radicals. ******Because iron absorption from the intestine is insufficient to meet daily erythroid demands,iron-recycling and re-utilization constitute important aspects of iron homeostasis. The cells responsible for efficiently recycling iron belong to the mononuclear phagocytic cells, which includes macrophages. One compartment in which tissue turnover is critical is the hematopoietic system. In the adult mouse, about 22 million lymphocytes are produced daily and, for their number to remain constant, an equal number of cells must die every day. However, practical and sensitive tools necessary to study temporal and spatial changes in tissue iron content are currently lacking.******Overall, we aim to understand how cells and organisms regulate their iron content, and how distinct tissues coordinate iron distribution in response to altered iron homeostasis.******We propose to unravel several essential aspects ofiron homeostasis: the regulation of cellular iron uptake and recycling, intestinal iron absorption, and brain iron metabolism.****** We expect that this fundamental research will make significant contributions to the field of iron biology and animal physiology. Because iron metabolism shares remarkable similarities in mammals and iron is essential for biological systems, the knowledge gained by studying iron metabolism in mice may very well become pertinent to more applied fields, such as human health and animal husbandry.

铁的吸收，利用和储存在小鼠 ** 总铁缺乏是不相容的生活，而铁过量是危险的毒性。因此，哺乳动物体内的铁水平保持平衡。铁代谢受到调节，从而为身体需要提供足够的铁（几乎每个细胞，特别是红细胞），但同时通过安全储存在专门的分子中避免其毒性，因为游离铁可以参与自由基的形成。 ** 因为从肠道吸收的铁不足以满足日常红细胞的需求，铁的回收和再利用构成了铁稳态的重要方面。负责有效回收铁的细胞属于单核吞噬细胞，包括巨噬细胞。造血系统是组织更新至关重要的一个部分。在成年小鼠中，每天产生约2200万个淋巴细胞，为了保持其数量恒定，每天必须有相同数量的细胞死亡。然而，目前缺乏研究组织铁含量时空变化所需的实用和敏感工具。总的来说，我们的目标是了解细胞和生物体如何调节其铁含量，以及不同的组织如何协调铁分布以应对铁稳态的改变。我们建议解开铁稳态的几个基本方面：细胞铁吸收和再循环，肠道铁吸收和脑铁代谢的调节。我们期望这项基础研究将为铁生物学和动物生理学领域做出重大贡献。由于铁代谢在哺乳动物中具有显着的相似性，并且铁对生物系统至关重要，因此通过研究小鼠铁代谢获得的知识很可能与更多应用领域相关，例如人类健康和畜牧业。