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Investigating the impact of polyglutamine expansion on the DNA damage response of ataxin-1 in the context of spinocerebellar ataxia type 1

Investigating the impact of polyglutamine expansion on the DNA damage response of ataxin-1 in the context of spinocerebellar ataxia type 1
研究 1 型脊髓小脑共济失调中多聚谷氨酰胺扩增对 ataxin-1 DNA 损伤反应的影响
批准号：
416734
负责人：
Suart Celeste
金额：
$7.65万
依托单位：
McMaster University
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-11-01 至 2022-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=416734&lang=en
关键词：
Ataxia Cag Triplet Repeat Disorder Cell Biology Dna Damage Microscopy Neurodegeneration Polyglutamine Expansion Disease Spinocerebellar Ataxia Type 1

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中文摘要
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英文摘要
Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by a mutation in the ATXN1 gene. Patients first begin to lose their balance and motor control, followed by difficulty speaking and swallowing food, and then cognitive decline. Symp
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