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Impact of disease-induced dysbiotic microbiota on the protective functions of innate T cells during type 1 diabetes

Impact of disease-induced dysbiotic microbiota on the protective functions of innate T cells during type 1 diabetes
疾病引起的失调微生物群对 1 型糖尿病期间先天 T 细胞保护功能的影响
批准号：
428925
负责人：
Kuypers Meggie
金额：
$1.27万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-12-01 至 2020-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=428925&lang=en
关键词：
Dysbiosis Fecal Transplant Human Microbiota-Associated (Hma) Mice Innate-Like T Lymphocytes Invariant Natural Killer T (Inkt) Cells Microbiota Mucosal-Associated Invariant T (Mait) Cells Type 1 Diabetes Unconventional T Lymphocytes

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"Type I diabetes (T1D) is an autoimmune disease characterized by abnormal immune responses that attack insulin-producing cells in the pancreas. In addition to genetic susceptibility, alterations in intestinal microbiota composition - called dysbiosis - ha
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