Defining the link between CDK2 activity and lineage-specific cancer susceptibility to RB loss

定义 CDK2 活性与谱系特异性癌症对 RB 丢失的易感性之间的联系

• 批准号: 428930
• 负责人: Lai Christian C
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-12-01 至 2020-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=428930&lang=en
• 关键词: Cancer Susceptibility; Cdk2 Activity; Cell Cycle Length; Human Embryonic Stem Cells; Live Cdk2 Sensor; Lung Organoids; Retinoblastoma; Small Cell Lung Cancer

"Gene defects that are oncogenic in one lineage are impotent in another. Understanding these dramatic differences in cancer susceptibility could expose new therapeutic vulnerabilities. RB is frequently mutated in retinoblastoma and small cell lung cancer

“在一个谱系中致癌的基因缺陷在另一个谱系中是无能的。了解癌症易感性的这些巨大差异可能会暴露出新的治疗弱点。RB常在视网膜母细胞瘤和小细胞肺癌中发生突变