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Defining the link between CDK2 activity and lineage-specific cancer susceptibility to RB loss

Defining the link between CDK2 activity and lineage-specific cancer susceptibility to RB loss
定义 CDK2 活性与谱系特异性癌症对 RB 丢失的易感性之间的联系
批准号：
428930
负责人：
Lai Christian C
金额：
$1.27万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-12-01 至 2020-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=428930&lang=en
关键词：
Cancer Susceptibility Cdk2 Activity Cell Cycle Length Human Embryonic Stem Cells Live Cdk2 Sensor Lung Organoids Retinoblastoma Small Cell Lung Cancer

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中文摘要
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英文摘要
"Gene defects that are oncogenic in one lineage are impotent in another. Understanding these dramatic differences in cancer susceptibility could expose new therapeutic vulnerabilities. RB is frequently mutated in retinoblastoma and small cell lung cancer
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