Synergising nanoemulsion and lipid biomimetic design for advanced delivery

该项目旨在确定脂质修饰探针或药物（脂质仿生物）的脂质配方的关键设计特征，这些成分共同促进脂质吸收途径的整合，并以排出小肠的淋巴系统为目标。这具有重大的潜力，因为肠淋巴系统是一个关键的免疫组织，是对自身抗原和来自食物和微生物组的抗原的免疫反应的部位。该项目将提供淋巴靶向所需特性的设计路线图，特别是将确定与脂质仿生协同工作的新型脂质纳米乳液，以增强淋巴成像和输送应用。

This project aims to identify the critical design characteristics of lipid formulations of lipid-modified probes or drugs (lipid biomimetics) that together promote integration into lipid absorption pathways and target the lymphatic system that drains the small intestine. This has significant potential since the intestinal lymphatic system is a key immune tissue, the site of immune response to autoantigens and antigens derived from food and the microbiome. The project will deliver a design roadmap of the required characteristics for lymphatic targeting, and in particular, will identify novel lipid nanoemulsions that work synergistically with lipid biomimetics to enhance lymphatic imaging and delivery applications.