Social modulation of and by pain in mice and humans

小鼠和人类疼痛的社会调节

• 批准号: RGPIN-2018-03873
• 负责人: Mogil, Jeffrey
• 金额: $ 3.42万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=689576
• 关键词: Social; modulation; pain; mice; humans

Findings from HQP in my laboratory have suggested that empathy, affiliation and prosocial behaviour can be demonstrated and studied in rodents as well as humans, in a completely translational manner from one species to another. For example, we have found that in both humans and mice that only familiars demonstrate emotional contagion of (i.e., empathy for) pain, and in both species emotional contagion among strangers is blocked by the hypothalamic-pituitary-adrenal stress response. More recently, we have found that in humans, like in mice, females engage in social approach behaviour to others in pain, whereas males do not. The proposed research program is designed to continue to investigate parallel social phenomena affecting pain, and parallel effects of pain on social behaviour, in both mice and humans. We will do so using the most ethologically relevant techniques practical in both species. Social psychology experiments in human participants will involve a variety of social interactions, presentation of chemosignals, and pain testing using the cold-pressor task. In mice, we will institute a visible burrow system in the laboratory to study social behaviours without the major confounds of stress inherent in both laboratory animal husbandry and laboratory behavioural testing. Since our data obtained to date in this domain shows robust sex differences, we will also attempt to further investigate the nature of these differences. This will be achieved partly using a developmental perspective, to assess whether differences observed in young adults can also be seen in pediatric and mature adult populations. It is anticipated that these studies will have implications for our understanding of the role of genetics versus sociocultural influences on social phenomena such as empathy and prosociality, and for sex versus gender differences therein.

我实验室的HQP研究结果表明，同理心，从属关系和亲社会行为可以在啮齿动物和人类中以完全翻译的方式从一个物种到另一个物种进行展示和研究。例如，我们发现，在人类和小鼠中，只有熟悉的人表现出情绪传染（即，同情）疼痛，在这两个物种中，陌生人之间的情绪传染被下丘脑-垂体-肾上腺应激反应所阻断。最近，我们发现，在人类中，就像在老鼠中一样，女性在疼痛中对其他人进行社会接近行为，而男性则没有。拟议的研究计划旨在继续研究影响疼痛的平行社会现象，以及疼痛对小鼠和人类社会行为的平行影响。我们将使用在这两个物种中最实用的行为学相关技术。在人类参与者中进行的社会心理学实验将涉及各种社会互动，化学信号的呈现以及使用冷加压任务的疼痛测试。在小鼠身上，我们将在实验室中建立一个可见的洞穴系统来研究社会行为，而不会出现实验室动物饲养和实验室行为测试中固有的压力的重大混乱。由于我们迄今为止在这一领域获得的数据显示出强大的性别差异，我们也将试图进一步研究这些差异的性质。这将部分使用发展的角度来实现，以评估在年轻人中观察到的差异是否也可以在儿科和成年人人群中看到。预计这些研究将对我们理解遗传学与社会文化对社会现象（如同理心和亲社会性）的影响以及其中的性别与性别差异的作用产生影响。