Interrogating the structural basis for protein interactions underlying mitochondrial calcium uniporter regulation in cardiomyocytes.

探究心肌细胞中线粒体钙单向转运蛋白调节的蛋白质相互作用的结构基础。

• 批准号: 420557
• 负责人: Stathopulos Peter B
• 金额: $ 49.04万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-03-01 至 2025-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=420557&lang=en
• 关键词: Calcium Signaling; Mcu Regulating Protein-1; Mitochondrial Calcium Uniporter; Myocardial Infarction; Protein Allostery; Protein Structure; Protein-Protein Interactions; Solution Nmr

Cancer and heart disease are responsible for almost 50 % of all deaths in Canada annually. In the past ten years these leading causes of mortality in both sexes have accounted for more than 1,250,000 Canadian deaths. Mitochondria are small compartments in

癌症和心脏病是加拿大每年死亡人数的近50%。在过去十年中，这些主要的男女死亡原因导致加拿大1 250 000多人死亡。线粒体是细胞中的小隔间