Chronic Obstructive Bladder Disease: Persistent Smooth Muscle Responses to the Damaged Microenvironment

慢性阻塞性膀胱疾病：平滑肌对受损微环境的持续反应

• 批准号: 431732
• 负责人: Bagli Darius J
• 金额: $ 7.29万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-03-01 至 2021-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=431732&lang=en
• 关键词: Bladder Obstruction; Chronic Obstructive Bladder Disease Cobd; Dna Methylation; Epigenetics; Histone Modification; Micro Rnas; Pearson Physiology Correlation; Regeneration; Single Cell Rnaseq

Bladder obstruction is common. Outflow in males is frequently blocked by prostate overgrowth, in females and children of all ages by neurologic or acquired outlet discoordination, and in male infants from obstructing urethral valves. After relief of obstr

膀胱梗阻很常见。男性的尿流经常因前列腺过度生长而受阻，所有年龄段的女性和儿童的尿流经常因神经系统或后天性出口不协调而受阻，而男性婴儿的尿流则因尿道瓣膜阻塞而受阻。解除障碍后