Canada Research Chair in Evolutionary Biophysics and Population Dynamics

进化生物物理学和种群动力学的CRC将整合蛋白质生物物理学，进化生物学和种群遗传学，以解决分子和微生物进化的基本问题。我的研究主要集中在两个主题上：(1)开发多尺度方法来预测耐药性的进化；(2)在分子和蛋白质进化中开发新的生物信息学工具。主题15的成功可能导致最佳给药方案，以提高抗微生物药物的效力和使用时间，这目前是一个重大的全球健康危机。主题2的成功可能会带来新的遗传学工具，以了解蛋白质和基因组的进化起源。

The CRC in Evolutionary Biophysics and Population Dynamics will integrate protein biophysics, evolutionary biology, and population genetics to address fundamental problems in molecular and microbial evolution. My research focuses on two themes: (1) Developing a multiscale approach to predict the evolution of drug resistance and (2) Developing novel bioinformatics tools in molecular and protein evolution. Theme 1s success could lead to optimal drug dosing regimen to increase the efficacy and duration of use of antimicrobials, currently a major global health crisis. Theme 2s success could lead to novel tools in genetics to understand the evolutionary origins of proteins and genomes.