Nonequilibrium Statistical Biophysics

非平衡统计生物物理学

• 批准号: 1000230775-2015
• 负责人: Sivak, David
• 金额: $ 8.74万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693241
• 关键词: Nonequilibrium; Statistical; Biophysics

Living things must maintain orderly structures and processes to function effectively; organisms avoid the inherently disordered state of equilibrium via constant input of high-energy food and output of low-energy waste. Using such energy efficiently should provide an evolutionary advantage. Theoretical far-from-equilibrium analysis of biomolecules (like ATP synthase, the protein producing the widely-used chemical currency ATP) will uncover physical constraints on microscopic energy conversion and design principles for efficient biological function. This work will illuminate evolutionary pressures, and the knowledge gained will aid the design of molecular devices for sustainable energy harvesting, efficient information storage and manipulation, or targeted drug delivery.

生物必须维持有序的结构和过程才能有效地发挥作用；生物体通过不断输入高能量食物和输出低能量废物来避免固有的无序平衡状态。有效地利用这种能量应该会带来进化优势。生物分子（如 ATP 合酶，产生广泛使用的化学货币 ATP 的蛋白质）的理论远平衡分析将揭示微观能量转换的物理限制和有效生物功能的设计原理。这项工作将阐明进化压力，所获得的知识将有助于设计用于可持续能量收集、有效信息存储和操作或靶向药物输送的分子装置。