Therapeutic Use of Micro-Sponge Embedded Nutritional Liquid Scaffold for Treatment of Non-Healing Wounds

微海绵嵌入营养液体支架治疗不愈合伤口的治疗用途

• 批准号: 538811-2019
• 负责人: Ghahary, Aziz
• 金额: $ 9.88万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693478
• 关键词: Therapeutic; Use; Micro; Sponge; Embedded

Problems and Solution: Chronic pressure ulcer (PU) is among the top five leading causes of re-hospitalization in patients with spinal cord injury (SCI) which frequently leads to infections, low quality of life, depression, and even a risk of death. The cost of treating PU in patients with SCI in Canada and BC alone is estimated to be $365.7 and $49.7 million / year, respectively. Treatment of PUs is challenging due to 3 major problems:1) The presence of cavities and void spaces which makes them difficult to to treat by conventional regiments, 2) Locating over bony prominence and weight-bearing parts of the body with a high risk of recurrence, 3) A high chance of infection before and during treatment. To solve these difficulties, we have recently addressed the 1st problem by developing and using liquid nutritional scaffold called MeshFill in our ongoing pilot clinical trial. However, more studies are needed to address the other problems. Thus, in this study, a new product, referred as to MeshFill-Plus consists of: 1) liquid nutritional scaffold (MeshFill), 2) Spongy and flexible nanofiberous skeleton and 3) Antibacterial nano-silver particles will be generated and tested for its functionally in infected and control wounds initially in the lab and then in a pre-clinical pig wound model which has a similar skin to human. Finally, evidence related to the safety and capability of the tested and optimized MeshFill-Plus will be submitted to University of British Columbia / Vancouver General Hospital Ethic Board for approval of small clinical feasibility study for treating 12 patients with PUs. The use MeshFill-Plus not only fills up all cavities/ tunnels from bottom up, it increases the physical strength of healed wounds and prevents the growth of any potential germs when applied on PUs. Conclusion: The result of this study makes it possible to assemble the components of MeshFill-Plus in a medical package for treating not only PUs, but also other non-healingwounds

慢性压疮（PU）是脊髓损伤（SCI）患者再次住院的五大主要原因之一，常导致感染、生活质量下降、抑郁，甚至有死亡风险。仅在加拿大和不列颠哥伦比亚省，治疗脊髓损伤患者PU的费用估计分别为3.657亿美元和4970万美元/年。脓液的治疗是具有挑战性的，主要有3个问题：1)存在空腔和空隙，这使得它们难以通过传统疗法治疗；2)位于骨突出和身体承重部位，复发风险高；3)治疗前和治疗期间感染的可能性高。为了解决这些困难，我们最近解决了第一个问题，在我们正在进行的试点临床试验中，我们开发和使用了名为MeshFill的液体营养支架。然而，需要更多的研究来解决其他问题。因此，在本研究中，一种名为meshfil - plus的新产品将由：1)液体营养支架（MeshFill）， 2)海绵状柔韧的纳米纤维骨架和3)抗菌纳米银颗粒组成，并首先在实验室中测试其在感染和控制伤口中的功能，然后在临床前具有相似皮肤的猪伤口模型中进行测试。最后，经测试和优化的meshill - plus的安全性和能力相关证据将提交给不列颠哥伦比亚大学/温哥华总医院伦理委员会，以批准对12例脓毒症患者进行小型临床可行性研究。使用meshill - plus不仅可以自下而上地填充所有的空洞/隧道，还可以增加愈合伤口的物理强度，并防止脓液上任何潜在细菌的生长。结论：本研究的结果使meshill - plus的组成部分组装在一个医疗包中，不仅可以治疗脓液，还可以治疗其他不愈合的伤口