Novel Delivery System for High Dose Rate Intensity Modulated Brachytherapy with Yb-169 as a Radiation Source

以 Yb-169 作为放射源的高剂量率强度调制近距离放射治疗的新型输送系统

• 批准号: 523394-2018
• 负责人: AbbasinejadEnger, Shirin
• 金额: $ 12.18万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693954
• 关键词: Novel; Delivery; System; Dose; Rate

Radiotherapy is an effective and safe treatment for cancer. Approximately 50% of cancerpatients benefit from this treatment, that is, close to 100,000 Canadians with cancer eachyear. Brachytherapy, is a form of radiotherapy where radioactive sources are placed inside ornear the tumours using thin, hollow tubes (catheters) implanted for a short period of time,giving a high radiation dose to the tumour while maintaining a low dose to surrounding healthy tissues. However, dose distribution in conventional brachytherapy is identical in all directions resulting in dose spillage to radiation sensitivehealthy tissues. This proposal aims to develop a novel radiation delivery system that willmanipulate the radiation dose to conform to the shape of a tumour by incorporating radiationshields inside the implanted hollow tubes, i.e. the delivery system will modulate the intensityof the emitted radiation from the brachytherapy source. The shields can rotate during thetreatment, direct the radiation towards the tumour and away from healthy tissues. Developing and making intensitymodulated brachytherapy clinically available, will significantly improve the potential ofbrachytherapy with reduced toxicity will increase the cure rates and improve the quality of lifefor Canadians with prostate, breast, cervical, uterine, vaginal, vulvar, head & neck andoesophageal cancers. In addition, this proposal will offer undergraduate and graduate studentto work in a multidisciplinary environment with radiation oncology, radiation physics, biology,computing and engineering.

放射治疗是一种有效和安全的癌症治疗方法。大约50%的癌症患者受益于这种治疗，也就是说，每年有近10万加拿大人患有癌症。近距离放射治疗是一种放射疗法，其中放射源被放置在肿瘤内部或附近，使用短时间内植入的薄中空管（导管），对肿瘤给予高辐射剂量，同时对周围健康组织保持低剂量。然而，在传统的近距离放射治疗中，剂量分布在所有方向上都是相同的，导致剂量溢出到辐射敏感的健康组织。该提案旨在开发一种新型的辐射输送系统，该系统将通过在植入的中空管内结合辐射屏蔽来操纵辐射剂量以符合肿瘤的形状，即输送系统将调制从近距离放射治疗源发射的辐射的强度。防护罩可以在治疗过程中旋转，将辐射导向肿瘤，远离健康组织。发展和使调强近距离放射治疗在临床上可用，将显着提高近距离放射治疗的潜力，降低毒性，提高治愈率，改善加拿大人前列腺癌、乳腺癌、宫颈癌、子宫癌、阴道癌、外阴癌、头颈癌和食道癌的生活质量。此外，该提案将为本科生和研究生提供在放射肿瘤学、放射物理学、生物学、计算和工程学等多学科环境中工作的机会。