Structure and function of the HDAC3 transcriptional co-repression complex

HDAC3转录共抑制复合物的结构和功能

• 批准号: 433835
• 负责人: Priv Gilbert G
• 金额: $ 69.66万
• 依托单位: Princess Margaret Cancer Centre (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=433835&lang=en
• 关键词: Electron Cryomicroscopy; Histone Deacetylases; Molecular Recognition; Protein Complexes; Protein Interaction Networks; Protein-Protein Interactions; Structural Biology; Transcriptional Corepressors; Transcriptional Regulation; X-Ray Crystallography

Cancer is a disease of unregulated cell growth. Within each cell there is a complex network of interacting proteins that determines whether the cell will remain stable, divide or die. In cancer cells, there are defects in the protein network that keep cel

癌症是一种细胞生长不受控制的疾病。在每个细胞内，有一个相互作用的蛋白质的复杂网络，它决定了细胞是保持稳定、分裂还是死亡。在癌细胞中，阻止细胞死亡的蛋白质网络存在缺陷。