Molecular Ecology of Waterborne Microbes

水生微生物的分子生态学

• 批准号: CRC-2019-00395
• 负责人: Dong, Tao
• 金额: $ 7.29万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=695431
• 关键词: Molecular; Ecology; Waterborne; Microbes

Microbes not only exist ubiquitously in the environment but also live within us human beings. They are not silently sitting in the audience but enthusiastic game players that work together to modulate macroscale functions from nitrogen fixation and biodegradation to human health. This research investigates the competitive interactions among microbes focusing on how bacteria gain resistance to antibiotics, natural microbial weapons that we have harnessed for decades, and alternative weapons bacteria employ to kill other bacteria. This research will generate important mechanistic insights regarding microbial competition and novel strategies as antibiotic alternatives to control antimicrobial resistance.

微生物不仅普遍存在于环境中，而且也生活在我们人类体内。他们不是静静地坐在观众席上，而是热情的游戏玩家，他们共同努力，调节从固氮和生物降解到人类健康的宏观功能。这项研究调查了微生物之间的竞争性相互作用，重点是细菌如何获得对抗生素的抗性，我们已经利用了几十年的天然微生物武器，以及细菌用来杀死其他细菌的替代武器。这项研究将产生关于微生物竞争的重要机制见解和作为控制抗生素耐药性的抗生素替代品的新策略。