Genomics and the Environment

该研究计划解决了对环境化学品的人类健康风险评估现代化的迫切需要，以提高效率，降低成本，并减少毒理学测试所需的大量动物。其主要目标是开发和部署量化有毒化学品如何调节基因功能或损害遗传物质（即基因组学）的方法，并利用这些信息预测人类的毒理学效应。该计划连接基础科学和应用科学，汇集学术界和政府的研究和监管团体，以推进监管流程和决策。

This research program addresses an urgent need to modernize human health risk assessment of environmental chemicals to increase efficiency, reduce cost, and reduce the large numbers of animals required for toxicological testing. The main objective is to develop and deploy approaches that quantify how toxic chemicals can modulate the function of genes or damage genetic material (ie, genomics), and use this information to predict toxicological effects in humans. The program bridges basic and applied sciences, bringing together the research and regulatory communities in academia and government to advance regulatory processes and decision-making.