Computational Biochemistry

计算生物化学

• 批准号: 1000232154-2018
• 负责人: Musgaard, Maria
• 金额: $ 8.74万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=696064
• 关键词: Computational; Biochemistry

Ligand-gated ion channels (LGICs) allow the flux of ions across biological membranes and are implicated in human health. Despite being considered as attractive pharmaceutical targets, many LGICs are not yet well understood in terms of their function and impact on health and disease. With the goal of designing better drugs, Dr. Musgaards approach is to use computational chemistry methods to understand the fundamental activation and regulation mechanisms of two LGICs, namely acid-sensing ion channels and ryanodine receptors. This understanding will improve the prospects of treating a myriad of conditions including heart disease, chronic pain disorders and psychiatric disorders.

配体门控离子通道（LGIC）允许离子穿过生物膜，并与人类健康有关。尽管被认为是有吸引力的药物靶点，但许多LGIC在其功能和对健康和疾病的影响方面尚未得到很好的理解。为了设计更好的药物，Musgaards博士的方法是使用计算化学方法来了解两种LGIC的基本激活和调节机制，即酸敏感离子通道和ryanodine受体。这种理解将改善治疗包括心脏病，慢性疼痛障碍和精神疾病在内的各种疾病的前景。