Molecular mechanisms of host shutoff by respiratory viruses and their contribution to viral pathogenesis

呼吸道病毒关闭宿主的分子机制及其对病毒发病机制的贡献

• 批准号: 433938
• 负责人: Khaperskyy Denys
• 金额: $ 41.8万
• 依托单位: Dalhousie University (Nova Scotia)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=433938&lang=en
• 关键词: Coronavirus; Host Shutoff; Influenza Virus; Innate Immune Responses; Non-Structural Protein 1 (Ns1); Non-Structural Protein 1 (Nsp1); Polymerase Acidic Protein X (Pa-X); Protein-Protein Interactions

Viral respiratory disease burden remains high despite continuous efforts to limit virus infection and spread through vaccination, surveillance, and quarantine measures. Now the world is in the middle of a pandemic caused by a novel respiratory virus - sev

尽管通过疫苗接种、监测和隔离措施不断努力限制病毒感染和传播，但病毒性呼吸道疾病负担仍然很高。现在，世界正处于一场由新型呼吸道病毒引起的大流行病之中--严重急性呼吸道综合征病毒