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Single-cell approaches to characterize and target the cellular reservoirs of HIV infection

Single-cell approaches to characterize and target the cellular reservoirs of HIV infection
表征和靶向 HIV 感染细胞库的单细胞方法
批准号：
433516
负责人：
Chomont Nicolas
金额：
$56.29万
依托单位：
Centre hospitalier de l'Universit de Montral (CHUM)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2020
资助国家：
加拿大
项目状态：
未结题
起止时间：
2020-10-01 至 2025-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=433516&lang=en
关键词：
Bone Marrow Central Memory Cd4+ T Cells Flow Cytometry Hiv Reservoir Latency Lymph Node Nef T Cell Proliferation T Cell Receptor (Tcr) Tissues

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中文摘要
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英文摘要
Antiretroviral therapy blocks HIV replication and extends the life of people living with HIV (PLHIV). However, it does not eliminate the virus and should be taken for life. In addition to persistent stigma, lifelong treatment entails both health risks to
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Interfering with HIV persistence in CD4+ T cells during antiretroviral therapy