Single-cell approaches to characterize and target the cellular reservoirs of HIV infection

表征和靶向 HIV 感染细胞库的单细胞方法

• 批准号: 433516
• 负责人: Chomont Nicolas
• 金额: $ 56.29万
• 依托单位: Centre hospitalier de l'Universit de Montral (CHUM)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=433516&lang=en
• 关键词: Bone Marrow; Central Memory Cd4+ T Cells; Flow Cytometry; Hiv Reservoir; Latency; Lymph Node; Nef; T Cell Proliferation; T Cell Receptor (Tcr); Tissues

Antiretroviral therapy blocks HIV replication and extends the life of people living with HIV (PLHIV). However, it does not eliminate the virus and should be taken for life. In addition to persistent stigma, lifelong treatment entails both health risks to

抗逆转录病毒疗法阻断艾滋病毒复制，延长艾滋病毒感染者的寿命。但是，它不能消除病毒，应该终身服用。除了持续的耻辱，终身治疗还带来健康风险，