Dietary choline and betaine in the prevention and treatment of feline obesity
膳食胆碱和甜菜碱预防和治疗猫肥胖
基本信息
- 批准号:472710-2016
- 负责人:
- 金额:$ 10.89万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Collaborative Research and Development Grants
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With a prevalence of more than 50% in industrialised countries, obesity represents a major health risk for the feline population, especially as obese cats are predisposed to devastating health complications that have a large negative impact on the quality of life and reduce life span. Moreover, current spay/neuter practices are known to be a major risk factor for fat deposition and development of obesity. Weight reduction is recommended in overweight cats yet current weight-loss programs tend to have disappointing outcomes and are not without risks. During periods of severe energy restriction, obesity predisposes cats to hepatic lipidosis, which is characterized by fat accumulation in the liver. Although the precise pathogenesis remains a mystery, it is believed that specific characteristics of feline protein and fat metabolism are involved. Dietary choline and betaine are metabolically linked to fat metabolism and may pose a benefit when treating and preventing obesity in cats. Choline as the precursor of phosphatidylcholine, a structural component of very-low-density lipoproteins, accelerates the removal of fat from the liver. Furthermore, choline and its derivate betaine, being methyl group donors, enhance the hepatic synthesis of carnitine, which is known to promote fat oxidation. In livestock, betaine not only reduces fat accumulation in the liver, but also decreases abdominal storage of fat and improves carcass lean percentage. The objective of this research is to investigate the effect of dietary choline and betaine supplementation on energy and lipid metabolism in obese cats during an episode of energy restriction and in growing kittens following spay/neuter. This university-government-industry partnership will support future pet nutrition research opportunities and growth of the domestic and export pet food markets. Comprehensive understanding of the molecular mechanisms of pet obesity and how these mechanisms are affected by functional foods that uncouple energy metabolism will lead to the development of new nutritional strategies that will make maintaining an ideal body weight much easier, prevent obesity and related health consequences and improve lifespan and quality of life of pets.
肥胖症在工业化国家的患病率超过50%,是猫科动物群体的主要健康风险,特别是因为肥胖的猫易患毁灭性的健康并发症,对生活质量产生巨大的负面影响并缩短寿命。此外,已知目前的斯帕伊/绝育做法是脂肪沉积和肥胖发展的主要风险因素。减肥是建议超重的猫,但目前的减肥计划往往有令人失望的结果,并不是没有风险。在严重的能量限制期间,肥胖使猫易患肝硬化,其特征是脂肪在肝脏中积聚。虽然确切的发病机制仍然是一个谜,它被认为是猫的蛋白质和脂肪代谢的具体特点参与。饮食中的胆碱和甜菜碱与脂肪代谢有关,在治疗和预防猫的肥胖时可能会带来好处。胆碱作为磷脂酰胆碱的前体,是极低密度脂蛋白的结构成分,加速肝脏脂肪的清除。此外,胆碱及其衍生物甜菜碱,作为甲基基团供体,增强肉毒碱的肝脏合成,已知肉毒碱促进脂肪氧化。在家畜中,甜菜碱不仅可以减少肝脏中的脂肪积累,而且可以减少腹部脂肪储存,提高胴体瘦肉率。本研究的目的是探讨饮食中补充胆碱和甜菜碱对能量限制期间的肥胖猫和生长中的小猫在绝育后的能量和脂质代谢的影响。这种大学-政府-行业的伙伴关系将支持未来的宠物营养研究机会和国内和出口宠物食品市场的增长。全面了解宠物肥胖的分子机制,以及这些机制如何受到功能性食品的影响,这些功能性食品将导致新的营养策略的发展,这将使保持理想的体重变得更加容易,预防肥胖和相关的健康后果,并提高宠物的寿命和生活质量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Verbrugghe, Adronie其他文献
Technology-enhanced weight-loss program in multiple-cat households: a randomized controlled trial.
- DOI:
10.1177/1098612x211044412 - 发表时间:
2022-08 - 期刊:
- 影响因子:1.7
- 作者:
Hadar, Barr N.;Lambrecht, Kenneth J.;Poljak, Zvonimir;Coe, Jason B.;Stone, Elizabeth A.;Verbrugghe, Adronie;Bernardo, Theresa M. - 通讯作者:
Bernardo, Theresa M.
An observational study of pet feeding practices and how these have changed between 2008 and 2018
- DOI:
10.1136/vr.105828 - 发表时间:
2020-06-27 - 期刊:
- 影响因子:2.2
- 作者:
Dodd, Sarah;Cave, Nick;Verbrugghe, Adronie - 通讯作者:
Verbrugghe, Adronie
The importance of assessing body composition of dogs and cats and methods available for use in clinical practice
- DOI:
10.2460/javma.251.5.521 - 发表时间:
2017-09-01 - 期刊:
- 影响因子:1.9
- 作者:
Santarossa, Amanda;Parr, Jacqueline M.;Verbrugghe, Adronie - 通讯作者:
Verbrugghe, Adronie
Plant-based diets for dogs
- DOI:
10.2460/javma.253.11.1425 - 发表时间:
2018-12-01 - 期刊:
- 影响因子:1.9
- 作者:
Dodd, Sarah A. S.;Adolphe, Jennifer L.;Verbrugghe, Adronie - 通讯作者:
Verbrugghe, Adronie
Does canine inflammatory bowel disease influence gut microbial profile and host metabolism?
- DOI:
10.1186/s12917-016-0736-2 - 发表时间:
2016-06-16 - 期刊:
- 影响因子:2.6
- 作者:
Xu, Jia;Verbrugghe, Adronie;Hesta, Myriam - 通讯作者:
Hesta, Myriam
Verbrugghe, Adronie的其他文献
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{{ truncateString('Verbrugghe, Adronie', 18)}}的其他基金
The role of the gut microbiota in feline energy metabolism
肠道微生物群在猫能量代谢中的作用
- 批准号:
RGPIN-2014-04518 - 财政年份:2022
- 资助金额:
$ 10.89万 - 项目类别:
Discovery Grants Program - Individual
The role of the gut microbiota in feline energy metabolism
肠道微生物群在猫能量代谢中的作用
- 批准号:
RGPIN-2014-04518 - 财政年份:2021
- 资助金额:
$ 10.89万 - 项目类别:
Discovery Grants Program - Individual
Dietary choline and betaine in the prevention and treatment of feline obesity
膳食胆碱和甜菜碱预防和治疗猫肥胖
- 批准号:
472710-2016 - 财政年份:2021
- 资助金额:
$ 10.89万 - 项目类别:
Collaborative Research and Development Grants
Nutritional suitability of a plant-based diet for maintenance of healthy adult dogs
植物性饮食对维持成年犬健康的营养适宜性
- 批准号:
530333-2018 - 财政年份:2020
- 资助金额:
$ 10.89万 - 项目类别:
Collaborative Research and Development Grants
Nutritional suitability of a plant-based diet for maintenance of healthy adult dogs
植物性饮食对维持成年犬健康的营养适宜性
- 批准号:
530333-2018 - 财政年份:2019
- 资助金额:
$ 10.89万 - 项目类别:
Collaborative Research and Development Grants
The role of the gut microbiota in feline energy metabolism
肠道微生物群在猫能量代谢中的作用
- 批准号:
RGPIN-2014-04518 - 财政年份:2019
- 资助金额:
$ 10.89万 - 项目类别:
Discovery Grants Program - Individual
Dietary choline and betaine in the prevention and treatment of feline obesity
膳食胆碱和甜菜碱预防和治疗猫肥胖
- 批准号:
472710-2016 - 财政年份:2019
- 资助金额:
$ 10.89万 - 项目类别:
Collaborative Research and Development Grants
The role of the gut microbiota in feline energy metabolism
肠道微生物群在猫能量代谢中的作用
- 批准号:
RGPIN-2014-04518 - 财政年份:2018
- 资助金额:
$ 10.89万 - 项目类别:
Discovery Grants Program - Individual
Nutritional suitability of a plant-based diet for maintenance of healthy adult dogs
植物性饮食对维持成年犬健康的营养适宜性
- 批准号:
530333-2018 - 财政年份:2018
- 资助金额:
$ 10.89万 - 项目类别:
Collaborative Research and Development Grants
Dietary choline and betaine in the prevention and treatment of feline obesity
膳食胆碱和甜菜碱预防和治疗猫肥胖
- 批准号:
472710-2016 - 财政年份:2018
- 资助金额:
$ 10.89万 - 项目类别:
Collaborative Research and Development Grants
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- 批准年份:2024
- 资助金额:0.0 万元
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Dietary choline and betaine in the prevention and treatment of feline obesity
膳食胆碱和甜菜碱预防和治疗猫肥胖
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472710-2016 - 财政年份:2021
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$ 10.89万 - 项目类别:
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472710-2016 - 财政年份:2019
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$ 10.89万 - 项目类别:
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膳食胆碱和甜菜碱预防和治疗猫肥胖
- 批准号:
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- 资助金额:
$ 10.89万 - 项目类别:
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9756226 - 财政年份:2018
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$ 10.89万 - 项目类别:
Dietary choline and betaine in the prevention and treatment of feline obesity
膳食胆碱和甜菜碱预防和治疗猫肥胖
- 批准号:
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Gut flora metabolism of dietary phosphatidylcholine and cardiovascular disease
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8656400 - 财政年份:2010
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