Investigating how TRAF1 Controls Inflammasome Activation in Animal Disease Models of Inflammatory Arthritis and Peritonitis

研究 TRAF1 如何控制炎症性关节炎和腹膜炎动物疾病模型中的炎症小体激活

• 批准号: 449429
• 负责人: Raspanti Jonathan
• 金额: $ 1.27万
• 依托单位: York University (Toronto, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2021-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=449429&lang=en
• 关键词: Auto Immune Diseases; Crystal-Induced Arthritis; Crystal-Induced Peritonitis; Il-1ß; Inflammasome; Inflammation; Peritonitis; Rheumatoid Arthritis; Traf1

IL-1β is a potent cytokine that is released as a part of the innate defense mechanism to invading pathogens. Activation of the NLRP3 inflammasome plays a crucial role in appropriate secretion of IL-1β, and its malfunctioning is a driver of autoi

白介素1是一种强有力的细胞因子，作为对入侵病原体的天然防御机制的一部分而被释放。NLRP3炎症体的激活在IL-1和β1的适当分泌中起着关键作用，其功能障碍是自身免疫性疾病的驱动因素