Modelling the interactome of Diphtheria Toxin with the promiscuous biotinylating enzyme TurboID

使用混杂生物素化酶 TurboID 对白喉毒素的相互作用组进行建模

• 批准号: 449373
• 负责人: Allott Jennifer S
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2021-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=449373&lang=en
• 关键词: Bacterial Pathogen; Bacterial Toxin; Infectious Disease; Interactome; Protein Biochemistry; Protein-Protein Interactions; Therapeutics

Toxins secreted by bacterial pathogens cause the tissue damage observed in many infectious diseases. Multi-domain protein toxins bind to host cell receptors and enter the cell through a process that is poorly understood, ultimately inactivating key host f

由细菌病原体分泌的毒素引起在许多传染病中观察到的组织损伤。多结构域蛋白毒素结合宿主细胞受体，并通过一个尚不清楚的过程进入细胞，最终使关键的宿主细胞失活。