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Investigation of ion-coupled solute cotransport: Structure/function studies of the rabbit Na+/D-glucose cotransporter (SGLT1)

Investigation of ion-coupled solute cotransport: Structure/function studies of the rabbit Na+/D-glucose cotransporter (SGLT1)
离子耦合溶质协同转运的研究：兔 Na /D-葡萄糖协同转运蛋白 (SGLT1) 的结构/功能研究
批准号：
178994
负责人：
Silverman Melvin
金额：
$7.29万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2008
资助国家：
加拿大
项目状态：
已结题
起止时间：
2008-09-01 至 2009-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=178994&lang=en
关键词：
Chemical Modification By Methanethiosulphonate Derivatives Cos-7 Cell Expression Cysteine Mutagenesis Electrophysiology Using 2-Electrode Voltage Clamp Fluorescence Ion-Coupled Solute Cotransport Isotope Uptake

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英文摘要
Our focus is a unique protein called SGLT1, expressed on the surface of cells in the intestine, kidney and lung. By an as yet unknown mechanism, SGLT1 transports in a tightly coupled fashion two Na+ ions and one sugar molecule, from the exterior into
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