Splice variant and paralog specific analysis of the gamma secretase - amyloid precursor protein complexome
Splice variant and paralog specific analysis of the gamma secretase - amyloid precursor protein complexome
批准号:
176204
负责人:
Schmitt-Ulms Gerold
金额:
$7.29万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2008
资助国家:
加拿大
项目状态:
已结题
起止时间:
2008-09-01 至 2009-09-01
中文摘要
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英文摘要
A key event in the molecular manifestation of Alzheimer disease is the aberrant proteolytic cleavage of the amyloid precursor protein (APP) by a multi-protein enzyme complex referred to as gamma-secretase. Attempts to devise a therapeutic strategy that ta
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