Golgi versus endocytic trafficking in the delivery of major histocompatibility complex II molecules to antigen-loading compartments

高尔基体与内吞运输在将主要组织相容性复合物 II 分子递送至抗原装载区室中的比较

• 批准号: 449820
• 负责人: Lac Alex
• 金额: $ 1.27万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2021-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=449820&lang=en
• 关键词: Antigen Presentation; Erc1; Halotag; Immune Evasion; Immunoprecipitation; Major Histocompatibility Complex Class Ii (Mhc Ii); Sars-Cov-2; Time-Lapse Microscopy; Trafficking Pathways

Antigen presentation on MHC II is crucial for generating immune responses against pathogens. Unfortunately, many pathogens-including SARS-CoV-2-can suppress immune responses by impairing this process. While the mechanisms for this immune evasion is known

抗原在MHC II上的呈递对于产生针对病原体的免疫反应至关重要。不幸的是，包括sars - cov在内的许多病原体可以通过破坏这一过程来抑制免疫反应。虽然这种免疫逃避的机制是已知的