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Macrophage Contributions Towards the Sarcoma Immune Architecture and Response to Stimulator of Interferon Genes Agonist Therapies

Macrophage Contributions Towards the Sarcoma Immune Architecture and Response to Stimulator of Interferon Genes Agonist Therapies
巨噬细胞对肉瘤免疫结构的贡献以及对干扰素基因激动剂治疗刺激剂的反应
批准号：
449492
负责人：
Hildebrand Kurt N
金额：
$1.27万
依托单位：
University of Calgary
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2020
资助国家：
加拿大
项目状态：
已结题
起止时间：
2020-12-01 至 2021-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=449492&lang=en
关键词：
Immunotherapy Macrophage Depletion Macrophages Mouse Sarcoma Soft Tissue Sarcoma Solid Tumour Sting Cancer Therapy

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Undifferentiated pleomorphic sarcoma (UPS) is an aggressive, highly metastatic malignant tumour of muscle. UPS is resistant to all available systemic therapies and metastatic disease is rapidly fatal. New UPS therapies are desperately needed. The STING (S
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