Macrophage Contributions Towards the Sarcoma Immune Architecture and Response to Stimulator of Interferon Genes Agonist Therapies

巨噬细胞对肉瘤免疫结构的贡献以及对干扰素基因激动剂治疗刺激剂的反应

• 批准号: 449492
• 负责人: Hildebrand Kurt N
• 金额: $ 1.27万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2021-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=449492&lang=en
• 关键词: Immunotherapy; Macrophage Depletion; Macrophages; Mouse; Sarcoma; Soft Tissue Sarcoma; Solid Tumour; Sting Cancer Therapy

Undifferentiated pleomorphic sarcoma (UPS) is an aggressive, highly metastatic malignant tumour of muscle. UPS is resistant to all available systemic therapies and metastatic disease is rapidly fatal. New UPS therapies are desperately needed. The STING (S

未分化多形性肉瘤（UPS）是一种侵袭性、高度转移的肌肉恶性肿瘤。 UPS 对所有可用的全身疗法都有抵抗力，并且转移性疾病会迅速致命。迫切需要新的 UPS 疗法。刺痛 (S