Probing the conformational dynamics of the frameshift-stimulatory pseudoknot of SARS-CoV-2 at the single-molecule level.

在单分子水平上探讨 SARS-CoV-2 移码刺激假结的构象动力学。

• 批准号: 441053
• 负责人: Munshi Sneha
• 金额: $ 9.83万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=441053&lang=en
• 关键词: -1 Programmed Frameshift In Virus; Binding Studies- Surface Plasmon Resonance; Enzymatic Assay; Single Molecule Studies - Optical Tweezers

The virus causing the COVID-19 pandemic, SARS-CoV-2, uses a process called -1 programmed ribosomal frameshifting (-1 PRF) to express proteins essential for viral replication. -1 PRF involves a change in the way the viral genome is read that is triggered b

引起 COVID-19 大流行的病毒 SARS-CoV-2 使用一种称为 -1 程序性核糖体移码 (-1 PRF) 的过程来表达病毒复制所必需的蛋白质。 -1 PRF 涉及病毒基因组读取方式的改变，该改变是由 b 触发的。