Developing a polygenic score to aid in the prediction of cisplatin-induced ototoxicity

开发多基因评分以帮助预测顺铂引起的耳毒性

• 批准号: 449433
• 负责人: Sarvis MacKenzie A
• 金额: $ 1.27万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-12-01 至 2021-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=449433&lang=en
• 关键词: Adverse Drug Reactions; Audiology; Cisplatin-Induced Ototoxicity; Genome-Wide Association Study; Hearing Loss; Inner Hair Cells; Pediatric Oncology; Pharmacogenomics; Polygenic Scores; Precision Medicine

Cisplatin is a common and effective chemotherapy drug which is used to treat many different types of cancer, and as with many chemotherapeutics, it harms both tumour and healthy cells. One of the most frequent adverse drug reactions seen with cisplatin is

顺铂是一种常见且有效的化疗药物，用于治疗许多不同类型的癌症，与许多化疗药物一样，它会损害肿瘤和健康细胞。顺铂最常见的药物不良反应之一是