Abnormal persistence of Cajal-Retzius cells and seizure susceptibility

Cajal-Retzius 细胞的异常持久性和癫痫易感性

• 批准号: 441563
• 负责人: Tan Qiumin
• 金额: $ 7.65万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-02-01 至 2024-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=441563&lang=en
• 关键词: Autophagy; Cajal-Retzius Cells; Epilepsy; Genetic Mouse Models; Hippocampus; Hyperexcitability; Mouse Behavioral Studies; Neural Activity; Neurodevelopment; Programmed Cell Death

Epilepsy affects about 1 in 200 children and adolescents in Canada. Treatment of epilepsy presents a complex challenge because it is caused by vastly different mechanisms that perturb the brain circuitry. As a result, 30%-40% of epilepsy patients do not r

在加拿大，癫痫症影响大约1/200的儿童和青少年。癫痫的治疗是一个复杂的挑战，因为它是由干扰大脑回路的截然不同的机制引起的。因此，30%-40%的癫痫患者不接受治疗。