Ultrasound Guidance and Monitoring of High-power Ultrasound Therapies

高功率超声治疗的超声引导和监测

• 批准号: RGPIN-2014-04548
• 负责人: Tavakkoli, Jahangir(Jahan)
• 金额: $ 1.38万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=708074
• 关键词: Ultrasound; Guidance; Monitoring; power; Therapies

Intensive focused ultrasound (IFUS), that encompasses high intensity focused ultrasound (HIFU) and histotripsy, is a high-power ultrasound therapy modality with a number of promising established and novel clinical applications. Magnetic resonance imaging (MRI) is currently considered as a gold standard imaging method for monitoring and control of HIFU therapy. However, a number of challenging problems including low temporal resolution, high cost, requirement for the use of MRI-compatible parts, and fitting requirement within the confined space of the MRI gantry, prohibited MRI to be adopted as a method of choice for clinical HIFU therapy monitoring and control. Ultrasound imaging is a relatively inexpensive, non-ionizing and real-time imaging modality that could seamlessly be integrated with an IFUS transducer. These attributes make ultrasound imaging a potentially suitable imaging modality for IFUS treatment monitoring and control. The current proposal aims to build upon PI's research activities in the area of ultrasound image-guided IFUS therapy in both modeling/simulation, and experiment/development aspects. The proposed research program is aimed towards: (a) expansion of current nonlinear ultrasound modeling and simulation algorithms, being developed by the PI and his research group, to include accurate and effective 3D nonlinear tissue temperature estimation and HIFU lesion generation dynamics prediction, and (b) expansion of current ultrasound-based methods, being developed by the PI and his research group, to develop new methods for real-time accurate and robust monitoring and control of HIFU therapies in tissue. Successful completion of the proposed research will bring ultrasound imaging into a competing position with the MRI for monitoring and control of HIFU therapies, which will, in turn, lead to a wider acceptance of HIFU as a non- or minimally-invasive therapy modality in a wide range of clinical applications.

密集聚焦超声（IFUS），包括高强度聚焦超声（HIFU）和组织破坏，是一种高功率超声治疗模式，具有许多有前途的既定和新的临床应用。磁共振成像（MRI）目前被认为是监测和控制HIFU治疗的金标准成像方法。然而，许多具有挑战性的问题，包括低时间分辨率、高成本、对使用MRI兼容部件的要求以及在MRI机架的有限空间内的装配要求，禁止采用MRI作为临床HIFU治疗监测和控制的选择方法。超声成像是一种相对便宜、非电离和实时的成像方式，可以与IFUS换能器无缝集成。这些属性使超声成像成为IFUS治疗监测和控制的潜在合适的成像模式。目前的提案旨在建立在PI在超声图像引导IFUS治疗领域的研究活动的基础上，包括建模/模拟和实验/开发方面。拟议的研究计划旨在：（a）扩展PI及其研究小组正在开发的当前非线性超声建模和模拟算法，以包括准确有效的3D非线性组织温度估计和HIFU损伤生成动力学预测，以及（B）扩展PI及其研究小组正在开发的当前基于超声的方法，开发新的方法，用于实时准确和强大的监测和控制组织中的HIFU治疗。拟议研究的成功完成将使超声成像与MRI在HIFU治疗的监测和控制方面处于竞争地位，这反过来将导致HIFU作为一种非侵入性或微创治疗方式在广泛的临床应用中得到更广泛的接受。