Investigations into sensing and metabolism of host lipids as a critical mediator of Staphylococcus aureus colonization and virulence

作为金黄色葡萄球菌定植和毒力关键介质的宿主脂质的传感和代谢研究

• 批准号: 445429
• 负责人: Mcgavin Martin J
• 金额: $ 44.03万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-04-01 至 2026-04-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=445429&lang=en
• 关键词: Acidic Ph; Antimicrobial Fatty Acid; Colonization; Environmental Stress; Gene Expression; Innate Immunity; Lipid Metabolism; Staphylococcus Aureus; Two Component Sensor System; Virulence

Approximately 30% of humans carry Staphylococcus aureus in their nose and on their skin. Although this represents an asymptomatic carrier state, S. aureus is also a leading cause of human infectious morbidity and mortality, and infections are caused by th

大约30%的人在鼻子和皮肤上携带金黄色葡萄球菌。虽然这代表了一个无症状的携带者状态，S。金黄色葡萄球菌也是人类感染发病率和死亡率的主要原因，