Dissecting the role and underlying mechanism of Surf4 in regulating lipid metabolism

解析Surf4在调节脂质代谢中的作用和潜在机制

• 批准号: 443644
• 负责人: Zhang Dawei
• 金额: $ 60.47万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-04-01 至 2026-04-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=443644&lang=en
• 关键词: Adeno-Associated Virus; Atherosclerosis; Cargo Receptor; Dyslipidemia; Gene Knockdown; Lipid Metabolism; Lipoprotein Secretion; Plasma Ldl Cholesterol; Triglyceride; Very Low Density Lipoprotein

Cardiovascular disease such as heart attack and stroke is the leading cause of death worldwide. Higher levels of cholesterol in blood, especially cholesterol from particles called low-density lipoproteins (LDL), are linked to higher risk of heart disease.

心脏病发作和中风等心血管疾病是全球主要的死亡原因。血液中的胆固醇水平较高，特别是来自低密度脂蛋白(LDL)颗粒的胆固醇，与心脏病的风险更高有关。