Interactions between hippocampal vesicular acetylcholine transporter (VAChT) loss and amyloid pathology in circuit and cognitive deficits in Alzheimer's disease

海马囊泡乙酰胆碱转运蛋白（VAChT）丢失与阿尔茨海默病回路中淀粉样蛋白病理和认知缺陷之间的相互作用

• 批准号: 455703
• 负责人: Prado Marco A
• 金额: $ 7.29万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=455703&lang=en
• 关键词: Alzheimer'S Disease; Cholinergic Signalling; Cognition; Fibre Photometry; Hippocampus; Miniscope; Neurodegeneration; Pathology; Touchscreens

Alzheimer's disease is thought to be caused by abnormal accumulation of amyloid beta proteins in the brain, which lead to neurodegeneration and dementia. However, most people over the age of 70 have amyloid in their brains, but the majority do not develop

人们认为阿尔茨海默氏病是由大脑中淀粉样蛋白β蛋白异常积累引起的，这会导致神经变性和痴呆。但是，大多数70岁以上的人的大脑都有淀粉样蛋白，但大多数人没有发展