Structure and Function of ABCG5/G8: a Sterol Transporter Implicated in Hypercholesterolemia and Atherosclerosis

ABCG5/G8 的结构和功能：与高胆固醇血症和动脉粥样硬化有关的甾醇转运蛋白

• 批准号: 451401
• 负责人: Lee Jyh-Yeuan
• 金额: $ 55.73万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-09-01 至 2026-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=451401&lang=en
• 关键词: Abcg5; Abcg8; Atp-Binding Cassette Transporter; Biophysics; Cardiovascular Diseases; Cholesterol; Cryo-Electron Microscopy; Hypercholesrolemia; Structural Biology; X-Ray Crystallography

The major goal of this study is to understand why rising level of cholesterol in our bodies causes cardiovascular diseases, the number one leading cause of deaths around the world. This phenomenon is called hypercholesterolemia, which causes abnormally hi

这项研究的主要目标是了解为什么我们体内胆固醇水平升高会导致心血管疾病，而心血管疾病是世界上第一大死亡原因。这种现象称为高胆固醇血症，它会导致异常的高胆固醇血症。