Applying our synthesis skills : natural products and molecular machinery

应用我们的合成技能：天然产物和分子机械

• 批准号: RGPIN-2019-05301
• 负责人: Spino, Claude
• 金额: $ 2.11万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=715453
• 关键词: Applying; our; synthesis; skills; natural

There are two distinct research programs in our application, each will be summarized in turn. Organic synthesis: Practicing and developing the science of synthesis are important endeavors. The pharmaceutical and agrochemical industries, among others, use synthetic methods and reagents that academics develop. In addition, we provide well trained and highly qualified people they can hire. We will endeavour to prepare several natural products: palau'amine is a complex natural alkaloid with a particularly strained high energy fragment notoriously difficult to make; plakortone and plakilactones are members of a biologically active family of polyketides that are promising therapeutics. In attempting their synthesis, we will be able to test the limits of our recently developed methodologies as well as invent new ones. Molecular switches: Another goal of synthesis is to prepare organic molecules possessing a function (organic devices). In order to make intelligent devices', the industry needs new molecular scaffolds that are able to respond to their environment or accomplish work when stimulated. We propose to make a novel molecular modulator with the aim of imparting control on useful systems. The system will respond to external stimuli (light, heat, chemicals, etc.). The system relies on controlling the equilibrium between to species called regioisomers. The aim is to switch from one species to the next upon applying an external stimulus. If we then hook' this switch onto a functional system, for example a conjugated system that displays fluorescence or conducts electricity, we would be able to turn it on' of off' by applying the external stimulus. There is immense potential in making nanomaterials and devices. The two scaffolds will be very good additions to a small but growing list of molecular devices. Our program will benefit all industries that require synthetics, both in terms of methods and HQP. In addition, I believe that organic synthesis as a lot to contribute to material chemistry and we hope to bring new ideas in that field.

在我们的申请中有两个不同的研究项目，每个项目将依次总结。 有机合成： 实践和发展综合科学是重要的努力。制药和农业化学工业等使用学术界开发的合成方法和试剂。此外，我们提供训练有素和高素质的人，他们可以雇用。我们将努力制备几种天然产物：帕劳'amine是一种复杂的天然生物碱，具有特别紧张的高能量片段，众所周知难以制备; plakortone和plakilactones是具有生物活性的聚酮化合物家族的成员，是有前途的治疗剂。在尝试对其进行综合时，我们将能够测试我们最近开发的方法的局限性并发明新的方法。 分子开关： 合成的另一个目标是制备具有功能的有机分子（有机器件）。为了制造智能设备，该行业需要新的分子支架，这些分子支架能够对环境做出反应或在受到刺激时完成工作。我们提出了一种新的分子调制器，其目的是赋予有用的系统的控制。该系统将响应外部刺激（光，热，化学品等）。该系统依赖于控制称为区域异构体的物质之间的平衡。其目的是在施加外部刺激时从一个物种切换到下一个物种。如果我们把这个开关连接到一个功能系统上，例如一个显示荧光或导电的共轭系统，我们就可以通过施加外部刺激来打开或关闭它。在制造纳米材料和器件方面有着巨大的潜力。这两个支架将是一个很好的补充，一个小的，但不断增长的分子器件名单。 我们的计划将有利于所有需要合成材料的行业，无论是在方法和HQP方面。此外，我相信有机合成对材料化学有很大的贡献，我们希望在该领域带来新的想法。