Striking a balance: mapping the structural stability and mechanical and chemical responsiveness of collagen proteins

取得平衡：绘制胶原蛋白的结构稳定性以及机械和化学反应性

• 批准号: RGPIN-2020-04680
• 负责人: Forde, Nancy
• 金额: $ 3.64万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=717251
• 关键词: Striking; balance; mapping; structural; stability

Multicellular life is scaffolded by structures that maintain cells in the desired locations and organizations. Conventionally these scaffolds are viewed as rigid, unchanging supports laid down during development and unaltered except by injury or disease. Recent scientific advances are revealing instead that these extracellular scaffolds are highly dynamic, responsive to changes in their local microenvironment and communicating these changes to the cells they support, which in turn modify these scaffolds to adapt to their changed environment.

多细胞生命由维持细胞在所需位置和组织中的结构搭建而成。传统上，这些支架被视为在发育过程中放置的坚硬、不变的支架，除非受到伤害或疾病的影响，否则不会改变。相反，最近的科学进展表明，这些细胞外支架是高度动态的，对局部微环境的变化做出反应，并将这些变化传达给它们支持的细胞，细胞反过来修改这些支架以适应变化的环境。