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Uncovering metabolic vulnerabilities of central nervous system leukemia using metabolic profiling of cerebrospinal fluid and an in vivo CRISPR screen

Uncovering metabolic vulnerabilities of central nervous system leukemia using metabolic profiling of cerebrospinal fluid and an in vivo CRISPR screen
利用脑脊液代谢分析和体内 CRISPR 筛选揭示中枢神经系统白血病的代谢脆弱性
批准号：
457141
负责人：
Wong Alan Y
金额：
$7.65万
依托单位：
Harvard Medical School (Boston, Massachusetts)
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2021
资助国家：
加拿大
项目状态：
已结题
起止时间：
2021-10-01 至 2024-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=457141&lang=en
关键词：
Cerebrospinal Fluid Chemotherapy Toxicity Combination Therapy In Vivo Crispr Screen Mass Spectrometry Metabolism Patient Samples Pediatric Leukemia Survivors' Quality Of Life Xenograft Mouse Model

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Leukemia is the most common childhood cancer and the second greatest cause of pediatric cancer mortality in Canada. Chemotherapy directed to the central nervous system (CNS) is a critical part of treatment because leukemia that spreads there is often fata
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