Use of a novel transgenic mouse model to probe the molecular mechanisms of lipoprotein(a) pathogenicity in atherosclerotic vascular disease

使用新型转基因小鼠模型探讨脂蛋白（a）在动脉粥样硬化性血管疾病中致病性的分子机制

• 批准号: 458698
• 负责人: St. John Julia M
• 金额: $ 7.65万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-11-01 至 2024-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=458698&lang=en
• 关键词: Animal Models; Atherosclerosis; Gene Expression; Histopathology; Immunohistochemistry; Lipoprotein(A); Sc-Rnaseq; Vascular Disease

Diseases of the human cardiovascular system remain leading causes of disability and death worldwide. These diseases largely arise from a process called atherosclerosis, which involves the formation of diseased areas called plaques within the walls of arte

人类心血管系统疾病仍然是全世界致残和死亡的主要原因。这些疾病主要是由动脉粥样硬化引起的，动脉粥样硬化包括动脉壁内病变区域斑块的形成