Evaluating Senolytics as preventative treatment option for Lower Back Pain in SPARC-null mice

评估 Senolytics 作为 SPARC 缺失小鼠下背痛的预防性治疗选择

• 批准号: 458799
• 负责人: Mannarino Matthew
• 金额: $ 7.65万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-11-01 至 2024-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=458799&lang=en
• 关键词: Back Pain; Ex-Vivo Organ Culture; Immunochemistry; In-Vivo Model; Intervertebral Discs Degeneration; Magnetic Resonance Imaging (Mri); Senescence; Senolytics; Sparc-Null Mice; Sterile Inflammation

Intervertebral discs (IVD) are rings of cartilage found in the spine between the vertebrae. Their degeneration is one of the major causes of back pain, a condition that represents a serious socio-economic burden. Upon degeneration, the IVDs become inflame

椎间盘（IVD）是在椎骨之间的脊柱中发现的软骨环。它们的退化是背痛的主要原因之一，背痛是一种严重的社会经济负担。一旦退化，IVD就会发炎，