Large-scale study of patient-specific phenotypical, functional and proteomic differences in induced pluripotent stem cell-derived cardiomyocytes after hypoxic injury

缺氧损伤后诱导多能干细胞来源的心肌细胞的患者特异性表型、功能和蛋白质组差异的大规模研究

• 批准号: 458860
• 负责人: Derish Ida
• 金额: $ 7.65万
• 依托单位: Research Institute of the McGill University Health Centre
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-11-01 至 2024-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=458860&lang=en
• 关键词: Cardiac Differentiation; Cardiomyopathies; Heart Failure; Hypoxia; Induced Pluripotent Stem Cells; Patient-Specific Differences; Proteomics; Recovery

Heart attacks remain a leading cause of death worldwide and a major burden on the healthcare system, despite recent advances in medicine. During a heart attack, damage to heart cells can occur from a stop of blood flow and a subsequent oxygen restriction,

尽管医学最近取得了进展，心脏病仍然是全世界死亡的主要原因，也是医疗保健系统的主要负担。在心脏病发作期间，血流停止和随后的氧气限制可能会对心脏细胞造成损害，