Repurposing the FDA-approved antibiotic sulfaphenazole for neuroprotection post spinal cord injury to improve motor and cardiovascular function

重新利用 FDA 批准的抗生素磺胺苯唑用于脊髓损伤后的神经保护，以改善运动和心血管功能

• 批准号: 459039
• 负责人: Fossey Mary P
• 金额: $ 7.65万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-11-01 至 2024-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=459039&lang=en
• 关键词: Autonomic Nervous System; Cardiac Function And Structure; Drug Repurposing; Heart Catheterization; Histology; Mass Spectrometry; Neuroprotection; Rna Sequencing; Spinal Cord Injury; Viral Tracing

The spinal cord transmits signals from the brain to the rest of the body to perform important bodily functions. When the spinal cord is injured, brain signals might not reach below the level of injury. This lack of brain signaling can lead to devastating

脊髓将信号从大脑传输到身体的其他部位，以执行重要的身体功能。当脊髓受伤时，大脑信号可能达不到损伤水平以下。这种大脑信号的缺乏可能会导致毁灭性的