Investigating the effects of maternal folic acid over-supplementation on offspring beta-cell proliferation, epigenetic regulation of genes, and vascularization of the pancreas

研究母亲过量补充叶酸对后代 β 细胞增殖、基因表观遗传调控和胰腺血管化的影响

• 批准号: 458998
• 负责人: Lofft Zoe
• 金额: $ 7.65万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-11-01 至 2024-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=458998&lang=en
• 关键词: Developmental Genetics; Developmental Programming; Dietary Manipulation; Dna Methylation; Epigenetics; Folate; Pancreas; Rna-Sequencing

Folate is a critical nutrient required for development. Folic acid (FA), the synthetic form of folate, has been fortified into grain products in Canada, which has greatly reduced neural tube defects. Folate deficiency in Canadian women is now rare; many w

叶酸是发育所需的重要营养素。叶酸（FA）是叶酸的合成形式，在加拿大已被强化到谷物产品中，这大大减少了神经管缺陷。叶酸缺乏症在加拿大妇女现在是罕见的，许多妇女，