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Investigating the effects of maternal folic acid over-supplementation on offspring beta-cell proliferation, epigenetic regulation of genes, and vascularization of the pancreas

Investigating the effects of maternal folic acid over-supplementation on offspring beta-cell proliferation, epigenetic regulation of genes, and vascularization of the pancreas
研究母亲过量补充叶酸对后代 β 细胞增殖、基因表观遗传调控和胰腺血管化的影响
批准号：
458998
负责人：
Lofft Zoe
金额：
$7.65万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2021
资助国家：
加拿大
项目状态：
已结题
起止时间：
2021-11-01 至 2024-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=458998&lang=en
关键词：
Developmental Genetics Developmental Programming Dietary Manipulation Dna Methylation Epigenetics Folate Pancreas Rna-Sequencing

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Folate is a critical nutrient required for development. Folic acid (FA), the synthetic form of folate, has been fortified into grain products in Canada, which has greatly reduced neural tube defects. Folate deficiency in Canadian women is now rare; many w
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