Investigating the role of oncogenic histone H3.3K27M mutations in pediatric diffuse intrinsic pontine glioma

研究致癌组蛋白 H3.3K27M 突变在儿童弥漫性脑桥胶质瘤中的作用

• 批准号: 458960
• 负责人: Lubanszky Evan
• 金额: $ 7.65万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-11-01 至 2024-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=458960&lang=en
• 关键词: Diffuse Intrinsic Pontine Glioma; Diffuse Midline Glioma - H3k27m Mutant; Epigenetics; H3k27m Mutant; Oncohistones; Pediatric High Grade Glioma; Synthetic Lethality; Transgenic Mouse Modeling

Diffuse Intrinsic Pontine Glioma (DIPG) is a devastating disease that is the leading cause of brain-tumour related death in children, for which there is no effective treatment. There are many factors that contribute to this lack of treatments, including t

弥漫性内源性脑桥胶质瘤（DIPG）是一种毁灭性的疾病，是儿童脑肿瘤相关死亡的主要原因，目前尚无有效的治疗方法。导致缺乏治疗的因素有很多，包括