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Characterizing the nucleotide-binding domain leucine-rich repeat pyrin domain– containing 1B (Nlrp1b) inflammasome in the intestinal epithelium

Characterizing the nucleotide-binding domain leucine-rich repeat pyrin domain– containing 1B (Nlrp1b) inflammasome in the intestinal epithelium
表征肠上皮中含有 1B (Nlrp1b) 炎症小体的富含亮氨酸的重复热蛋白结构域的核苷酸结合结构域
批准号：
466750
负责人：
Mazzone Ryan J
金额：
$1.27万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2021
资助国家：
加拿大
项目状态：
已结题
起止时间：
2021-12-01 至 2022-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466750&lang=en
关键词：
Cell Signalling Enteric Parasite Infection Inflammasome Inflammatory Bowel Disease Innate Immunity Intestinal Inflammation Murine Intestinal Organoids Nod-Like Receptors Pyroptosis Regulated Cell Death

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英文摘要
The epithelial cells that line the intestine not only function in nutrient absorption, but also serve as a crucial barrier that protects against microbial infection. Within these cells, NOD-like receptors (NLRs) act as innate sentinels that respond to spe
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