Characterizing the nucleotide-binding domain leucine-rich repeat pyrin domain– containing 1B (Nlrp1b) inflammasome in the intestinal epithelium

表征肠上皮中含有 1B (Nlrp1b) 炎症小体的富含亮氨酸的重复热蛋白结构域的核苷酸结合结构域

• 批准号: 466750
• 负责人: Mazzone Ryan J
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466750&lang=en
• 关键词: Cell Signalling; Enteric Parasite Infection; Inflammasome; Inflammatory Bowel Disease; Innate Immunity; Intestinal Inflammation; Murine Intestinal Organoids; Nod-Like Receptors; Pyroptosis; Regulated Cell Death

The epithelial cells that line the intestine not only function in nutrient absorption, but also serve as a crucial barrier that protects against microbial infection. Within these cells, NOD-like receptors (NLRs) act as innate sentinels that respond to spe

肠道内壁的上皮细胞不仅具有营养吸收的功能，而且还是防止微生物感染的重要屏障。在这些细胞内，NOD 样受体 (NLR) 充当先天哨兵，对特定的