Investigating the impact of PGC-1a-coupled metabolic reprogramming on breast cancer metastasis

研究 PGC-1a 偶联代谢重编程对乳腺癌转移的影响

• 批准号: 467228
• 负责人: Ciccolini Emma R
• 金额: $ 1.27万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=467228&lang=en
• 关键词: Breast Cancer Metastasis; Breast Cancer Metastasis To The Lung; Cancer Associated Fibroblasts; Cancer Metabolism; Metabolic Coupling; Metabolic Flexibility; Peroxisome Proliferator-Activated Receptor Gamma-1alpha

An increasingly recognized feature of cancer is its ability to make alterations to metabolism to meet the high energy demands of rapidly growing tumours. The ability to reprogram their metabolism also helps cancer cells to better adapt to stressful condit

癌症的一个日益被认识到的特征是它能够改变新陈代谢以满足快速生长的肿瘤的高能量需求。重新编程其新陈代谢的能力也有助于癌细胞更好地适应压力条件。