Tracking Vaccine-Dependent B-cell Evolution as a Predictor of Vaccine Efficacy

追踪疫苗依赖性 B 细胞进化作为疫苗功效的预测因子

• 批准号: 467172
• 负责人: Nikolsky Anita
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=467172&lang=en
• 关键词: Affinity Maturation; Antibody Evolution; Antibody Selection; Antibody Sequencing; B-Cell Development; Memory B-Cells; Single-Cell Sequencing

The immune response to infectious molecules is highly dependent on the evolution of key immune cells. For instance, binding of a pathogenic molecule to a B cell elicits a cellular response to produce antibodies specific to the pathogen. This pathway follo

对感染分子的免疫反应高度依赖于关键免疫细胞的进化。例如，病原体分子与B细胞的结合会引起细胞反应，产生针对病原体的抗体。此路径遵循以下步骤